4. 155 Varick Street

The building on 155 Varick Street, or 50 Vandam Street, depending on the source, was once the headquarters of El Diario, which in 1963 was merged with La Prensa and became El Diario La Prensa, now the largest and oldest Spanish-language daily newspaper in the country. Today, it is the home of City Winery, a wine bar and restaurant that also hosts live musical performances.